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AM Markets Need to Know: FDA leadership changes, yield gap narrows, and more

Stock index futures were muted on Wednesday after Wall Street closed in the red on Tuesday as oil prices continued to climb.

Here are the five news items investors should watch:

FDA names permanent drug and vaccine chiefs: The Trump administration appointed Michael Davis and Karim Mikhail to permanently lead the FDA’s Center for Drug Evaluation and Research and Center for Biologics Evaluation and Research, respectively. The moves come as the White House advances broader changes at the agency, including the nomination of Heidi Overton as FDA commissioner. Investors will watch for potential implications for drug approvals, vaccines, and tobacco regulation.

HSBC cuts LVMH and Burberry ratings: HSBC downgraded LVMH (LVMHF) and Burberry (BURBY) to hold, citing limited visibility into the luxury sector’s second-half outlook. The bank set price targets of €490 for LVMH and 1,200 pence for Burberry while pointing to softer momentum across luxury goods. Shares fell 2.2% for LVMH and 3.1% for Burberry following the rating changes.

Equity-bond valuation gap tightens: The spread between equity earnings yields and government bond yields has narrowed across several developed markets as bond yields have climbed, according to Liz Ann Sonders. S&P Dow Jones Indices data showed the compression across the U.S., Canada, Japan, Australia, and the U.K. The shift could influence how investors assess the relative attractiveness of equities versus government bonds.

Iceland protests Trump map post: Iceland’s government summoned U.S. Ambassador Billy Long after President Donald Trump shared a social-media map depicting Iceland and many neighboring regions under the U.S. flag. Foreign Minister Thorgerdur Gunnarsdottir called the imagery unacceptable from Iceland’s perspective. The episode adds another point of diplomatic friction as markets monitor U.S. foreign policy developments.

NASA seeks lunar infrastructure proposals: NASA is seeking proposals from companies, universities, nonprofits, and international partners for technologies supporting a sustained human presence near the moon’s South Pole. The agency is focusing on power generation, oxygen extraction, and material production. The initiative could create opportunities for private-sector contractors as the U.S. expands its longer-term lunar exploration program.